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FLASH GENE
Symbol TUBB contributors: mct - updated : 06-01-2016
HGNC name tubulin, beta
HGNC id 20778
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
conjugated PhosphoP
mono polymer heteromer , dimer
HOMOLOGY
interspecies homolog to rattus Tubb5 (100 pc)
homolog to murine Tubb5 (100 pc)
Homologene
FAMILY
  • tubulin family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus
    basic FUNCTION
  • being the major constituent of microtubules
  • is necessary for the proper generation and migration of neurons
  • is essential for neuronal differentiation and dendritic spine formation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • dimer of alpha and beta chains
    • INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • cations such as calcium
  • GTP
    • protein
  • interaction between TRPV4 and tubulin beta 5 by associating together
  • ADAP2 interaction with TUBB involving the C-terminal region of TUBB
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CSCKT1 , CDCBM6
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS