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FLASH GENE
Symbol TUBB contributors: mct - updated : 06-01-2016
HGNC name tubulin, beta
HGNC id 20778
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
Nervousbrain    
Reproductivefemale systemovary   
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervousperipherous   
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES acid
STRUCTURE
motifs/domains
conjugated PhosphoP
mono polymer heteromer , dimer
HOMOLOGY
interspecies homolog to rattus Tubb5 (100 pc)
homolog to murine Tubb5 (100 pc)
Homologene
FAMILY
  • tubulin family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    intracellular,cytoplasm,cytoskeleton,microtubule
    intracellular,nucleus
    basic FUNCTION
  • being the major constituent of microtubules
  • is necessary for the proper generation and migration of neurons
  • is essential for neuronal differentiation and dendritic spine formation
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • dimer of alpha and beta chains
    • INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • cations such as calcium
  • GTP
    • protein
  • interaction between TRPV4 and tubulin beta 5 by associating together
  • ADAP2 interaction with TUBB involving the C-terminal region of TUBB
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) CSCKT1 , CDCBM6
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS