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FLASH GENE
Symbol LTA contributors: np/ - updated : 23-05-2007
HGNC name lymphotoxin alpha (TNF superfamily, member 1)
HGNC id 6709
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an extracellular C terminus, bearing the ligand binding region
    • conjugated GlycoP
    mono polymer homomer , heteromer , trimer
    HOMOLOGY
    Homologene
    FAMILY
  • tumors necrosis factor (ligand) family
    • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION     plasma membrane
    text membrane protein type 2
    basic FUNCTION
  • involved in the formation of secondary lymphoid organs during development and playing a role in apoptosis
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with LGALS2
    • cell & other
    REGULATION
    Other regulated by LGALS2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to myocardial infarction
  • to early-onset leprosy
  • to psoriatic arthritis
    • Variant & Polymorphism SNP , other
  • increased risk of myocardial infarction
  • (LTA)+80 A allele was significantly associated with an increase in early-onset leprosy risk
    • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cardiovascularatheromacardiac
    metabolismlipid 
    may represent a novel therapeutic route for the treatment of dyslipidemia
    ANIMAL & CELL MODELS