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FLASH GENE
Symbol LTA contributors: np/ - updated : 23-05-2007
HGNC name lymphotoxin alpha (TNF superfamily, member 1)
HGNC id 6709
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart    
Digestivepharynx    
Lymphoid/Immunespleen    
 tonsils    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/ImmuneT cell
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an extracellular C terminus, bearing the ligand binding region
    • conjugated GlycoP
    mono polymer homomer , heteromer , trimer
    HOMOLOGY
    Homologene
    FAMILY
  • tumors necrosis factor (ligand) family
    • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION     plasma membrane
    text membrane protein type 2
    basic FUNCTION
  • involved in the formation of secondary lymphoid organs during development and playing a role in apoptosis
    • CELLULAR PROCESS cell life, cell death/apoptosis
    PHYSIOLOGICAL PROCESS development
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
  • interacting with LGALS2
    • cell & other
    REGULATION
    Other regulated by LGALS2
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
  • to myocardial infarction
  • to early-onset leprosy
  • to psoriatic arthritis
    • Variant & Polymorphism SNP , other
  • increased risk of myocardial infarction
  • (LTA)+80 A allele was significantly associated with an increase in early-onset leprosy risk
    • Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    cardiovascularatheromacardiac
    metabolismlipid 
    may represent a novel therapeutic route for the treatment of dyslipidemia
    ANIMAL & CELL MODELS