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FLASH GENE
Symbol LTB contributors: - updated : 30-08-2007
HGNC name lymphotoxin beta (TNF superfamily, member 3)
HGNC id 6711
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an extracellular C terminus
  • a ligand binding region
    • conjugated GlycoP
    mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to murine Ltb (74.7 pc)
    homolog to rattus Ltb (75.8 pc)
    Homologene
    FAMILY
  • tumors necrosis factor (ligand) TNF superfamily
    • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text
  • single-pass type II membrane protein
    • basic FUNCTION
  • may play a specific role in immune response regulation
  • providing the membrane anchor for the attachment of the heterotrimeric complex to the cell surface
  • being the primary ligand for the lymphotoxin-beta receptor
  • being an inducer of the inflammatory response system
  • involved in normal development of lymphoid tissue
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • heterotrimer of either two LTB and one LTA subunits or (less prevalent) one LTB and two LTA subunits
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to LTBR/TNFRSF3
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS