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FLASH GENE
Symbol LTB contributors: - updated : 30-08-2007
HGNC name lymphotoxin beta (TNF superfamily, member 3)
HGNC id 6711
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Lymphoid/Immunelymph node   moderately
 spleen   moderately
 tonsils   predominantly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoietic    
cells
SystemCellPubmedSpeciesStageRna symbol
Lymphoid/Immunemacrophage
cell lineage
cell lines
fluid/secretion highly in lymph
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an extracellular C terminus
  • a ligand binding region
    • conjugated GlycoP
    mono polymer heteromer , trimer
    HOMOLOGY
    interspecies homolog to murine Ltb (74.7 pc)
    homolog to rattus Ltb (75.8 pc)
    Homologene
    FAMILY
  • tumors necrosis factor (ligand) TNF superfamily
    • CATEGORY signaling cytokine
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
    text
  • single-pass type II membrane protein
    • basic FUNCTION
  • may play a specific role in immune response regulation
  • providing the membrane anchor for the attachment of the heterotrimeric complex to the cell surface
  • being the primary ligand for the lymphotoxin-beta receptor
  • being an inducer of the inflammatory response system
  • involved in normal development of lymphoid tissue
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • heterotrimer of either two LTB and one LTA subunits or (less prevalent) one LTB and two LTA subunits
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • binding to LTBR/TNFRSF3
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS