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FLASH GENE
Symbol FYN contributors: mct/npt/pgu - updated : 17-08-2018
HGNC name FYN oncogene related to SRC, FGR, YES
HGNC id 4037
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a Src homolgy 2, a Src homology 3 domains
  • a K homology (KH) motif bound to a QUA2 motif (RNA binding)
  • a proteine kinase catalytic domain
    • HOMOLOGY
    interspecies homolog to rattus Fyn (99.63 pc)
    homolog to murine Fyn (94.19 pc)
    Homologene
    FAMILY
  • Src-family tyrosine kinases
  • Tyr protein kinase family
  • SRC subfamily (signal transduction)
  • STAR (signal transduction and activator of RNA) family
    • CATEGORY enzyme , protooncogene
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,mitochondria
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,endosome
    basic FUNCTION
  • non receptor tyrosine kinase, involved in T cell signaling regulation
  • also involved in protocadherin signaling
  • monopalmitoylated SFK required for VEGF mitogenic signaling with SRC and FYN, but maintaining distinct properties in the regulation of VEGF-mediated endothelial cell events
  • implicated in both brain development and adult brain function
  • in mast cell degranulation in interacting with both cytosolic and structural proteins
  • involved in mast cell degranulation in interacting with both cytosolic and structural proteins
  • may play an important role in HTR6- mediated signaling pathways in the central nervous system
  • involved in tyrosine phosphorylation of KIRREL (results in significantly increased KIRREL and TJP1 binding, suggesting a critical role for KIRREL tyrosine phosphorylation in reorganizing the KIRREL-TJP1 complex)
  • mediates chronic myelogenous leukemia cell proliferation
  • in part through its effects on DAB1, regulates the phosphorylation, trafficking, and processing of APP and LRP8
  • playing a role in exit from meiotic and mitotic metaphases and required for regulation of microtubules polymerization and spindle stabilization
  • play an essential role in signaling events that implicate spindle assembly checkpoint pathway and hence in regulating the exit from metaphase in oocytes and zygote
  • plays a key role in oligodendrocyte differentiation and myelination in the central nervous system
  • is an important signaling molecule in oligodendrocytes
  • FYN cooperates with oncogenic FLT3-ITD in cellular transformation by selective activation of the STAT5 pathway
  • MAGI2 and FYN protect DDN from NEDD4L-mediated ubiquitination and from nuclear translocation, thereby maintaining the physiologic homeostasis of podocytes, and the lack of MAGI2 in podocytes results in glomerulosclerosis
    • CELLULAR PROCESS cell life, proliferation/growth
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule metal binding, nucleotide,
  • ATP
  • Mn2+
    • protein
  • the cytoplasmic tail of protocadherins
  • ADD2 (colocalizing under plasma membranes)
  • binding to vimentin and pyruvate kinase
  • complexed with staurosporine
  • ARHGAP33 is a novel FYN substrate
  • interacting with brain-specific PTPRT (PTPRT regulates synapse formation through interaction with cell adhesion molecules, and this function and the phosphatase activity are attenuated through tyrosine phosphorylation by the synaptic tyrosine kinase FYN)
  • PTPRA is an important positive regulator of FYN activation and signaling that is required for the differentiation of oligodendrocyte progenitor cells (OPCs)
  • interaction with FYB, a FYN adapter protein expressed in podocytes, and TMEM47 possibly through FYB, may regulate FYN activity
  • SLIT2 regulates the dispersal of oligodendrocyte precursor cells through FYN and RHOA signaling
  • NCK1 directly modulates NPHS1 phosphorylation through formation of a signaling complex with the Src family kinase FYN
  • functional interaction between FYN, AGAP2, and STAT5A in mediating adipogenesis
  • UNC119 plays a key role in the FYN signal transduction pathway, which regulates the completion of cytokinesis via RAB11A
  • dynamic interaction between CAMK2D2 and FYN in VSM (Vascular smooth muscle) cells, indicating a mechanism by which CAMK2D2 and FYN may coordinately regulate VSM cell motility
  • SH2D1a plays an essential role in collagen-induced arthritis (CIA) because of FYN-independent and FYN-dependent effects on follicular T helper (TFH) cells and, possibly, other T cell types
  • MOBP levels are regulated by FYN kinase and affect the morphological differentiation of oligodendrocytes
  • DDN is phosphorylated by FYN and dephosphorylated by PTPN1, and FYN-induced phosphorylation prevents NEDD4L-mediated ubiquitination of dendrin
  • FYN has likely a regulatory role in NOS2 expression in astrocytes during neuroinflammatory responses
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral       gain of function
    activated in clear cell renal carcinoma with good outcome
    tumoral     --over  
    in chronic myelogenous leukemia blast crisis compared with chronic phase
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target therapies targeting Fyn expression for chronic myelogenous leukemia
    ANIMAL & CELL MODELS