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FLASH GENE
Symbol SPARC contributors: mct - updated : 02-07-2017
HGNC name secreted protein, acidic, cysteine-rich (osteonectin)
HGNC id 11219
ASSOCIATED DISORDERS
corresponding disease(s) OIXVII
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
higher expression significantly associated with lymph node metastasis, lymphatic invasion and perineural invasion
tumoral     --over  
in hepatocellular carcinoma, and in in many advanced cancers, including malignant gliomas
tumoral     --over  
in osteosarcoma, and correlated with the worst event and relapse free survival
tumoral     --over  
is able to inhibit cell proliferation in medulloblastoma cell lines
tumoral     --other  
aberrant expression of SPARC associated with an invasive tumor cell phenotype and poor outcome in human melanomas
constitutional       gain of function
SPARC, MMP2 and MM9 were significantly up-regulated in intracranial aneurysms relative to the expression levels in the normal Circle of Willis arteries
tumoral     --over  
in endometrial cancer stem-like cells
constitutional     --over  
during skeletal muscle regeneration and inhibits myoblast differentiation
Susceptibility
Variant & Polymorphism
Candidate gene
  • prognostic marker for gastric cancer
    • Marker
    Therapy target
    SystemTypeDisorderPubmed
    respiratorylung 
    may represent a novel therapeutic target in idiopathic pulmonary fibrosis
    diabete  
    could be a convergence point for insulin and PRKAA1 signaling, making it an attractive molecule for prospective pharmacological or genetic manipulation
    cancerbrain 
    therapeutic candidate for medulloblastoma treatment
    cancerhemopathy 
    is a potential therapeutic target for AML
    ANIMAL & CELL MODELS
  • Sparc-null mice exhibit significantly more fat accumulation than wild-type mice
  • Sparc-null mice develop progressive osteoporosis, due to a defect in bone formation
  • Sparc-null mice have lower intraocular pressure (IOP)
  • Sparc-null mice had increased synaptic connections in the superior colliculus