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FLASH GENE
Symbol ROS1 contributors: - updated : 17-11-2005
HGNC name v-ros UR2 sarcoma virus oncogene homolog 1 (avian)
HGNC id 10261
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a tyrosine kinase domain
  • a transmembrane domain
  • an extracellular domain carrying an N glycosylation site
    • conjugated GlycoP , PhosphoP
    HOMOLOGY
    interspecies homolog to avian UR2 sarcoma virus oncogene (v-ros)
    homolog to murine Ros1
    homolog to Drosophila sev
    homolog to C.elegans R151.4
    Homologene
    FAMILY sevenless subfamily of tyrosine kinase insulin receptor genes
    CATEGORY enzyme , protooncogene , receptor membrane tyrosine kinase
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I integral membrane protein
    basic FUNCTION
  • receptor tyrosine kinase,class II, functioning as a growth or differentiation factor receptor
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text sodium/potassium-transporting ATPase
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to myocardial infarction
    Variant & Polymorphism SNP increasing the risk of myocardial infarction
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS