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FLASH GENE
Symbol ROS1 contributors: - updated : 17-11-2005
HGNC name v-ros UR2 sarcoma virus oncogene homolog 1 (avian)
HGNC id 10261
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Respiratorylung    
cell lineage
cell lines variety of tumor cell lines highly
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a tyrosine kinase domain
  • a transmembrane domain
  • an extracellular domain carrying an N glycosylation site
    • conjugated GlycoP , PhosphoP
    HOMOLOGY
    interspecies homolog to avian UR2 sarcoma virus oncogene (v-ros)
    homolog to murine Ros1
    homolog to Drosophila sev
    homolog to C.elegans R151.4
    Homologene
    FAMILY sevenless subfamily of tyrosine kinase insulin receptor genes
    CATEGORY enzyme , protooncogene , receptor membrane tyrosine kinase
    SUBCELLULAR LOCALIZATION     plasma membrane
    text type I integral membrane protein
    basic FUNCTION
  • receptor tyrosine kinase,class II, functioning as a growth or differentiation factor receptor
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    text sodium/potassium-transporting ATPase
    PATHWAY
    metabolism
    signaling signal transduction
    a component
    INTERACTION
    DNA
    RNA
    small molecule nucleotide,
    ATP
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility to myocardial infarction
    Variant & Polymorphism SNP increasing the risk of myocardial infarction
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS