Selected-GenAtlas references	SOURCE	GeneCards	NCBI Gene	Swiss-Prot	Orphanet	Ensembl
	HGNC	UniGene	Nucleotide	OMIM		UCSC

Home Page

FLASH GENE

Symbol

PLG

contributors: mct - updated : 01-03-2017

HGNC name	plasminogen
HGNC id	9071

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

PLG , TRDP

Susceptibility

to Giant Cell Arteritis (GCA) to atherosclerosis and periodontitis

Variant & Polymorphism SNP	rs4252134 increasing the risk of GCA
	risk alleles in the genes CDKN2B-AS1, CAMTA1 and PLG that are shared between coronary artery disease (CAD) and periodontitis

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

	Plg deficiency attenuates postnatal erythropoiesis in male C57BL/6 mice through decreased activity of the LH-testosterone axis
	Plg(-/-) mice display decreased bone mineral density
	after induction of peritonitis by thioglycollate injection, we found that Plg(-/-) mice displayed diminished macrophage trans-ECM migration and decreased MMP9 activation