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FLASH GENE
Symbol PGC contributors: - updated : 15-11-2006
HGNC name progastricsin (pepsinogen C)
HGNC id 8890
Location 6p21.3-p21.1      Physical location : 41.704.449 - 41.715.139
EC.number 3.4.23.3
DNA
TYPE functioning gene
STRUCTURE 10.00 kb     9 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked Y status provisional
Map see GLO1
Physical map
UNC5CL 6p21.1 unc-5 homolog C (C. elegans)-like BZRPL1 6p21.1 benzodiazapine receptor (peripheral)-like 1 APOBEC2 6p21 apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 2 C6orf130 6p21.1 chromosome 6 open reading frame 130 NFYA 6p21.3 nuclear transcription factor Y, alpha LOC221442 6p21.1 hypothetical protein LOC221442 TREML1 6p21.1 triggering receptor expressed on myeloid cells-like 1 TREM2 6p21.1 triggering receptor expressed on myeloid cells 2 C6orf76 6p21.1 chromosome 6 open reading frame 76 LOC285852 6p21.1 hypothetical protein LOC285852 TREM1 6p21.1 triggering receptor expressed on myeloid cells 1 NCR2 6p21.1 natural cytotoxicity triggering receptor 2 FOXP4 6p21.1 forkhead box P4 MDFI 6p21 MyoD family inhibitor TFEB 6p21 transcription factor EB PGC 6p22-p12 progastricsin (pepsinogen C) FRS3 6p21.1 fibroblast growth factor receptor substrate 3 C6orf49 6p21.31 chromosome 6 open reading frame 49 MGC20741 6p21 ubiquitin specific protease 49 USP49 6p12.1 ubiquitin specific protease 49 BYSL 6p21.1 bystin-like CCND3 6p21 cyclin D3 TBN 6p21.1 taube nuss homolog (mouse) LOC389389 6 similar to hypothetical protein BC006605 GUCA1A 6p21.1 guanylate cyclase activator 1A (retina) GUCA1B 6p21.1 guanylate cyclase activator 1B (retina) MRPS10 6p21.1-p12.1 mitochondrial ribosomal protein S10 TRERF1 6p21.1-p12.1 transcriptional regulating factor 1 C6orf133 6p21.1 chromosome 6 open reading frame 133
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveesophagus   highly
 stomach   specific
Endocrinepancreas    
Nervousnervecranial nerve  moderately
Reproductivemale systemprostate   
Respiratorylung    
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 16 aa signal peptide
  • isoforms Precursor zymogen
    HOMOLOGY
    interspecies homolog to dog PGNB (62.8 pc)
    homolog to chimpanzee PGC (99 pc)
    homolog to rattus Pgc (74.7 pc)
    homolog to murine Pgc (74.8 pc)
    homolog to chicken CPGC (65.7 pc)
    Homologene
    FAMILY
  • peptidase A1 family
  • CATEGORY enzyme
    SUBCELLULAR LOCALIZATION extracellular
    basic FUNCTION
  • involved in proteolysis and peptidolysis
  • CELLULAR PROCESS protein, degradation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --low  
    in gastric cancer
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS