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FLASH GENE

Symbol

NT5E

contributors: mct/shn - updated : 12-06-2013

HGNC name	5'-nucleotidase, ecto (CD73)
HGNC id	8021

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in melanoma with with a highly invasive phenotype

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed dermatology skin   biochemical or biological inhibitors of ENTPD1 and/or NT5E may hold promise in the treatment of dermal fibrosis in diseases such as scleroderma

ANIMAL & CELL MODELS

ecto-5'-nucleotidase/CD73-deficient mice have a significantly reduced fall in stop flow pressure and superficial nephron glomerular filtration rate in response to a saturating increase of tubular perfusion flow (Castrop et al, 2004)