SUBCELLULAR LOCALIZATION
| plasma membrane
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| intracellular
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| intracellular,cytoplasm,organelle,lumen
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| intracellular,cytoplasm,organelle,membrane
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| intracellular,cytoplasm,organelle,endoplasmic reticulum
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| intracellular,cytoplasm,organelle,lysosome
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| intracellular,nuclear envelope,ext
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| text
| located in the outer membrane of the nuclear envelope  |
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localized to both the plasma membrane and the perinuclear region |
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NEU1 and NEU3 are present on erythrocyte plasma membrane |
| basic FUNCTION
| involved in stepwise degradation of complex type of oligosaccharide structure (glycoprotein catabolism), and cleavage of sialic acid from GM1 gangliosides |
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upregulated during T cell activation |
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can desialylate neighboring microfibrillar glycoproteins and facilitate the deposition of insoluble elastin, which contributes to the maintenance of cellular quiescence |
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desialylates and functionally inactivates adjacent receptors interacting with the mitogenic growth factors PDGF-BB and IGF2 |
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negatively regulates lysosomal exocytosis in hematopoietic cells by processing the sialic acids on the lysosomal membrane protein LAMP1 |
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targeted to the cell surface in a multiprotein complex that facilitates elastic fiber assembly |
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having a possible regulatory role in the early stages of myogenesis |
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negative regulator of lysosomal exocytosis |
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has been shown to regulate phagocytosis in macrophage cells |
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NEU1 and MMP9 in complex with TLR receptors at the ectodomain form a molecular organizational signaling platform on the cell surface that is essential for ligand activation of TLR receptors and cellular signaling |
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novel role as an intermediate in the initial process of ligand-induced TLR receptor activation and subsequent cellular signaling |
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NEU1 restrains endothelial cell migration, whereas NEU3 does not |
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its catalytic activity may offer an additional level of regulation over the airway epithelial response to ligands, pathogens, and injurious stimuli |
