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FLASH GENE
Symbol ITGA1 contributors: mlc - updated : 07-05-2007
HGNC name integrin, alpha 1
HGNC id 6134
Location 5p11.1      Physical location : 52.084.135 - 52.249.484
Synonym name verylate activation protein 1
Synonym symbol(s) CD49A, MSK11, VLA1
DNA
TYPE functioning gene
STRUCTURE 167.00 kb     29 Exon(s)
10 Kb 5' upstream gene genomic sequence study
MAPPING cloned Y linked   status confirmed
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type ubiquitous
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularheart   moderately
Digestiveesophagus   moderately
 liver   moderately
Endocrineadrenal gland   highly
Lymphoid/Immunelymph node   predominantly
 spleen   highly
Nervousnerve   moderately
Reproductivefemale systemuteruscervix moderately
 female systembreastmammary gland moderately
 female systemplacenta  moderately
 female systemuterus  highly
Urinarykidney   highly
Visualeyeanterior segmentcornea lowly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Connective   highly
Connectiveadipose  lowly
cell lineage
cell lines
fluid/secretion blood
at STAGE
physiological period embryo
Text embryonic tissue at a lowly level
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 28 amino acids signal peptide (3.0 kDa)
  • comprising a N terminal large extracellular domain consisting of a sevenfold repeated structure with putative cation-binding motifs in the three of four C terminal repeats and an I domain inserted between the second and third repeats ligand binding. This domain is connected by a single transmembrane segment (1TM) to a short conserved cytoplasmic domain
  • secondary structure an alpha and a beta subunit
    mono polymer heteromer , dimer
    isoforms Precursor a 1151 amino acids mature peptide (127.8 kDa)
    HOMOLOGY
    interspecies homolog to chimpanzee ITGA1 (99.58 pc)
    homolog to rattus Itga1 (87.86 pc)
    homolog to murine Itga1 (87.95 pc)
    Homologene
    FAMILY integrin alpha chain family
    CATEGORY adhesion , antigen , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • cell diffentiation antigen identified by monoclonal antibody SR84
  • cell surface adhesion receptor mediating cell-adhesion to extra cellular matrix or to other cells, through hetero dimerization and connecting to the cytoskeleton and various signaling molecules within cells
  • CELLULAR PROCESS cell communication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component dimerizing with ITGB1 in collagen, laminin receptors
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral        
  • activated in clear cell renal carcinomas with good outcome
  • Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS