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FLASH GENE
Symbol MAS1 contributors: mct - updated : 07-12-2011
HGNC name MAS1 oncogene
HGNC id 6899
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments (7TM) receptor
    • HOMOLOGY
    Homologene
    FAMILY
  • G-protein coupled receptor 1 family
    • CATEGORY protooncogene , receptor
    SUBCELLULAR LOCALIZATION     plasma membrane
    basic FUNCTION
  • may be a receptor that, when activated, modulates a critical component in a growth-regulating pathway to bring about oncogenic effects
  • ability of MAS1 to up-regulate AGTR1 levels reflects the constitutive capacity of MAS1 to activate GNA11 and hence stimulate PKC-dependent phosphorylation of the AGTR1
  • key role for the Ang-(1-7)/MAS1 axis as a modulator of cardiomyocyte function
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • Ang-(1-7)/MAS1 axis
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • stimulation of the MAS1 protein should result in increased nitric oxide, potentially nitrating the ZNF274/TRIM28 complex, resulting in dissociation of TRIM28 and activation of the transcription of MAS1
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS