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FLASH GENE

Symbol

MAS1

contributors: mct - updated : 07-12-2011

HGNC name	MAS1 oncogene
HGNC id	6899

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6q25.3      Physical location : 160.327.973 - 160.329.105
Synonym name	angiotensin receptor
Synonym symbol(s)	MGC119966, MAS, Ang-(1-7)/MAS

DNA

TYPE	functioning gene
STRUCTURE	1.13 kb     1 Exon(s)

10 Kb 5' upstream gene genomic sequence study

regulatory sequence	Promoter
	Binding site   transcription factor
text structure	promoter had the potential to be repressed by the human HMG box containing protein
	SRY (hSRY) binding sites for ZNF274, TRIM28, SP1 and HDAC2
	proximal promoter of MAS contains numerous potential SOX binding elements (

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002377 1 - 1135 37.33 325 - 1997 9441760

EXPRESSION

Type

expressed in

(based on citations)

organ(s)

System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Nervous brain forebrain       Mus musculus Adult   brain limbic system hippocampus     Mus musculus Adult Olfactory (smell) olfactory bulb         Mus musculus Adult Reproductive female system ovary       Homo sapiens   male system testis       Mus musculus Adult Urinary kidney         Mus musculus Adult

cells

System Cell Pubmed Species Stage Rna symbol Reproductive granulosa cell Homo sapiens

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

seven transmembrane segments (7TM) receptor

HOMOLOGY

Homologene

FAMILY

G-protein coupled receptor 1 family

CATEGORY

protooncogene , receptor

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	may be a receptor that, when activated, modulates a critical component in a growth-regulating pathway to bring about oncogenic effects
	ability of MAS1 to up-regulate AGTR1 levels reflects the constitutive capacity of MAS1 to activate GNA11 and hence stimulate PKC-dependent phosphorylation of the AGTR1
	key role for the Ang-(1-7)/MAS1 axis as a modulator of cardiomyocyte function

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

Ang-(1-7)/MAS1 axis

INTERACTION

DNA

RNA

small molecule

protein

stimulation of the MAS1 protein should result in increased nitric oxide, potentially nitrating the ZNF274/TRIM28 complex, resulting in dissociation of TRIM28 and activation of the transcription of MAS1

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS