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FLASH GENE

Symbol

IGF2R

contributors: shn/npt/pgu - updated : 02-02-2016

HGNC name	insulin-like growth factor 2 receptor
HGNC id	5467

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral   LOH     in hepatocellular carcinoma tumoral somatic mutation       in endometrial hyperplasia and other cancers (alteration of ligand binding) tumoral   LOH     in malignant adrenocortical tumor

Susceptibility

oral squamous cell carcinoma

Variant & Polymorphism SNP	variants are associated with fetal growth

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

Murine embryos that inherit a nonfunctional Igf2r gene from their fathers are normal whereas mice inherit the same mutated allele from their mothers die due to a major cardiac abnormalities