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FLASH GENE
Symbol MCM3 contributors: mct/npt/shn - updated : 11-11-2012
HGNC name minichromosome maintenance complex component 3
HGNC id 6945
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a nuclear localization signal (NLS)
  • a central ATPase/helicase region
  • a phosphorylation sites in the carboxyl terminus that may be sequestered from ATM-dependent checkpoint signals
    • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae replication Mcm3 (minichromosome maintenance mutant)
    ortholog to Mcm3, Mus musculus
    ortholog to Mcm3, Rattus norvegicus
    ortholog to mcm3, Danio rerio
    ortholog to MCM3, Pan troglodytes
    Homologene
    FAMILY
  • mini-chromosome maintenance (MCM) protein family
    • CATEGORY DNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,nucleoplasm
    basic FUNCTION
  • participating in the cell cycle control of genome duplication
  • may represent a glioma-associated antigen with significant prognostic role
  • CDK-dependent MCM3 phosphorylation contributes to the regulated formation of the MCM2-7 complex (Lin 2008)
  • during S phase MCM3 functions as part of the replicative helicase but within the pre-replication, MCM3 is inactive
  • role in controlling the S phase checkpoint of cell cycle
    • CELLULAR PROCESS cell cycle, checkpoint
    nucleotide, replication
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • MCM complex is a platform for multiple DNA damage-dependent regulatory signals that control DNA replication
    • INTERACTION
    DNA
  • chromatin
    • RNA
    small molecule
    protein
  • GANP
  • cyclin D1
  • MCM2, MCM4, MCM5, MCM6 and MCM7
  • Rad51 and Rad52
  • ORC2, MCM3, and DTD1 were bound at an ectopic MYC replicator, where deletion of sequences essential for origin activity was associated with the loss of DTD1 binding or the alteration of chromatin structure and loss of MCM3 binding
  • FACT
  • p29
  • MCM binding protein, MCM-BP
  • H4 histone
  • Metaphase Chromosome Protein 1, MCP1
  • Tax oncoprotein
    • cell & other
    REGULATION
    Phosphorylated by cyclin E/Cdk2
    Cdc7
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral     --over  
    in astrocytic tumors
    tumoral     --other  
    deregulation might be involved in medulloblastoma tumorigenesis (Lau 2010)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS
  • excess accumulation of MCM3 protein onto chromatin may inhibit DNA replication