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FLASH GENE

Symbol

MCM3

contributors: mct/npt/shn - updated : 11-11-2012

HGNC name	minichromosome maintenance complex component 3
HGNC id	6945

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_002388 17 splicing 3234 NP_002379 91 808 - - NM_001270472 16 splicing 3121 NP_001257401 - 818 - -

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a nuclear localization signal (NLS)
	a central ATPase/helicase region
	a phosphorylation sites in the carboxyl terminus that may be sequestered from ATM-dependent checkpoint signals

HOMOLOGY

interspecies	homolog to yeast S.cerevisiae replication Mcm3 (minichromosome maintenance mutant)
	ortholog to Mcm3, Mus musculus
	ortholog to Mcm3, Rattus norvegicus
	ortholog to mcm3, Danio rerio
	ortholog to MCM3, Pan troglodytes

Homologene

FAMILY

mini-chromosome maintenance (MCM) protein family

CATEGORY

DNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,nucleoplasm

basic FUNCTION	participating in the cell cycle control of genome duplication
	may represent a glioma-associated antigen with significant prognostic role
	CDK-dependent MCM3 phosphorylation contributes to the regulated formation of the MCM2-7 complex (Lin 2008)
	during S phase MCM3 functions as part of the replicative helicase but within the pre-replication, MCM3 is inactive
	role in controlling the S phase checkpoint of cell cycle

CELLULAR PROCESS	cell cycle, checkpoint
	nucleotide, replication

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

MCM complex is a platform for multiple DNA damage-dependent regulatory signals that control DNA replication

INTERACTION

DNA

chromatin

RNA

small molecule

protein	GANP
	cyclin D1
	MCM2, MCM4, MCM5, MCM6 and MCM7
	Rad51 and Rad52
	ORC2, MCM3, and DTD1 were bound at an ectopic MYC replicator, where deletion of sequences essential for origin activity was associated with the loss of DTD1 binding or the alteration of chromatin structure and loss of MCM3 binding
	FACT
	p29
	MCM binding protein, MCM-BP
	H4 histone
	Metaphase Chromosome Protein 1, MCP1
	Tax oncoprotein

cell & other

REGULATION

Phosphorylated by	cyclin E/Cdk2
	Cdc7

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in astrocytic tumors tumoral     --other   deregulation might be involved in medulloblastoma tumorigenesis (Lau 2010)

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS

excess accumulation of MCM3 protein onto chromatin may inhibit DNA replication