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FLASH GENE

Symbol

HINT1

contributors: mct - updated : 11-07-2016

HGNC name	histidine triad nucleotide binding protein 1
HGNC id	4912

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005340 3 - 689 NP_005331 - 126 - 1996 8812426

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive mouth       highly   salivary gland       highly Urinary bladder       highly

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

histidine triad (Hit) motif in the C-terminus, having a critical role on governing substrate specificity

secondary structure

a five-stranded antiparallele beta street and two alpha helices

mono polymer

homomer , dimer

HOMOLOGY

interspecies	homolog to murine Hint
	homolog to C.elegans F21C3.3

Homologene

FAMILY

histidine triad family of protein (HIT family)

CATEGORY

regulatory

SUBCELLULAR LOCALIZATION	plasma membrane
	intracellular
	intracellular,cytoplasm,cytoskeleton
	intracellular,nucleus

basic FUNCTION	cleaving a TP into AMP and inorganic phosphate by enzymatic activity
	intracellular receptor for purine mononucleotides
	involved in the regulation of apoptotic pathways by inducing an up-regulation of TP53 expression coinciding with an up-regulation of the proapoptotic factor BAX and a concomitant down-regulation of the apoptosis inhibitor BCL2
	its major function is to modulate OPRM1 signaling pathway along with RGS20, rather than directly mediating the GNAZ RGS20 interaction
	tumor suppressor function of HINT1 is caused by, at least in part, its normal role in enhancing cellular responses to DNA damage by regulating the functions of both H2AFX and ATM
	tumor suppressor activity of HINT1 gene in melanoma cells by promoting the formation of non-functional complexes with oncogenic transcription factors like MITF and CTNNB1
	catalyzes the hydrolysis of phosphoramidate and acyl adenylate with high efficiency, through a mechanism that relies on rapid adenylylation of the active residue, His112, while being partially rate-limited by intermediate hydrolysis and product release associated with a conformational change
	involved in the behavioral abnormalities induced by social isolation and exerts distinct roles in different encephalic regions

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

signal transduction

a component

INTERACTION

DNA

RNA

small molecule

protein	Protein kinase C
	CDK7
	ATDC
	interaction with Pontin and Reptin (inhibits T-cell factor/beta-catenin-mediated transcription of Wnt target genes)
	interacting with RGS20
	suppresses specific gene transcription by interacting with the transcription factor MITF in mast cells
	novel function of HINT1 that involves the regulation of SOC-mediated Ca(2+) entry pathway (ORAI1 and STIM1), essential for regulation of cellular Ca(2+) homeostasis
	HINT1 protein cooperates with CNR1 to negatively regulate glutamate NMDA receptor activity
	HINT1 is a human TENM1 intracellular domain (ICD) interaction partner
	inhibitory role of HINT1 on the protein PRKCG in the brain and an impaired PRKCG-mediated phosphorylation signal in HINT1-deficient neuron

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

NMAN

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS