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FLASH GENE
Symbol PPARD contributors: mct/npt/pgu - updated : 08-06-2016
HGNC name peroxisome proliferator-activated receptor delta
HGNC id 9235
ASSOCIATED DISORDERS
corresponding disease(s)
Other morbid association(s)
TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
tumoral     --over  
in colorectal carcinoma
Susceptibility
Variant & Polymorphism
Candidate gene
Marker
  • novel prognostic markers in acute myeloid leukemia with favorable outcome are PSMD2, PPARD
    • Therapy target
    SystemTypeDisorderPubmed
    diabetemetabolic syndrom 
    promising new target for the treatment of vascular diseases associated with metabolic disorders
    diabetemetabolic syndrom 
    PPARdelta agonists may have therapeutic usefulness in metabolic syndrome by increasing fatty acid consumption and decreasing obesity
    diabetetype 2 
    PPAR-delta agonists may have a potential for treating inflammatory diseases such as atherosclerosis and diabetes
    cardiovascularatheroma 
    may be a key target for therapeutic intervention in atherosclerosis by preventing cellular senescence of VSMCs
    neurologyacquired 
    pharmacological activation of PPARδ may provide a new therapeutic strategy to treat stroke-induced vascular and neuronal damage
    cardiovascular  
    PPARD activation can be a potential therapeutic target for cardiac disorders
    ANIMAL & CELL MODELS
  • targeted disruption of the mouse peroxisome proliferator-activated receptor beta results in growth, adipose, brain and skin alterations
  • endothelial-protective effect of Ppard agonists in diabetic mice through PI3K/Akt/eNOS signaling, suggesting the therapeutic potential of PPARD agonists for diabetic vasculopathy
  • long-term cardiomyocyte-restricted PPARdelta deficiency in mice leads to depressed myocardial fatty acid oxidation, bioenergetics, and premature death with lipotoxic cardiomyopathy