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FLASH GENE
Symbol SGCD contributors: npt/ - updated : 13-07-2006
HGNC name sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
HGNC id 10807
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • small intracellular domain
  • a single transmembrane hydrophobic domain
  • large extracellular C terminus with four cysteine residues
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Sgcd
    Homologene
    FAMILY
  • sarcoglycan beta/delta/gamma family
    • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
    text sarcolemmal type 2 membrane protein
    basic FUNCTION
  • forming a link between the f-actin cytoskeleton and the extracellular matrix
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • associating with other sarcoglycans and sarcospan in a stoichiometrically equal complex, stabilizing the link between dystroglycan and dystrophin/utrophin
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • dystrophin binding
  • utrophin DP116, SGCE and SGCB in the Schwann cell membrane
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LGMD2F
    related resource Limb-Girdle Muscular Dystrophy, Type 2F
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS