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FLASH GENE
Symbol SGCD contributors: npt/ - updated : 13-07-2006
HGNC name sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
HGNC id 10807
Corresponding disease
LGMD2F limb girdle muscular dystrophy 2F
Location 5q33.3      Physical location : 155.753.766 - 156.194.796
Synonym name
  • 35kD dystrophin-associated glycoprotein
  • delta-sarcoglycan
  • dystrophin associated glycoprotein, delta sarcoglycan
  • placental delta sarcoglycan
  • Synonym symbol(s) DAG35, DAGD, DAPA4D, CMD1L, SGD, 35DAG, CMD1L, DAGD, MGC22567, SG-delta, SGCDP
    DNA
    TYPE functioning gene
    STRUCTURE 441.03 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    motif Viral sequence   long terminal repeat
    text structure specific HERV-K LTR within intron 5
    MAPPING cloned Y linked N status confirmed
    Physical map
    C5orf3 5q31-q32 chromosome 5 open reading frame 3 MFAP3 5q32 microfibrillar-associated protein 3 GALNT10 5q33.2 UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 10 (GalNAc-T10) FLJ11526 5q33.2 hypothetical protein FLJ11526 HAND1 5q32 heart and neural crest derivatives expressed 1 LOC389339 5 LOC389339 LARP 5q33.2 likely ortholog of mouse la related protein C5orf4 5q31-q32 chromosome 5 open reading frame 4 CNOT8 5q31-q33 CCR4-NOT transcription complex, subunit 8 GEMIN5 5q33.3 gem (nuclear organelle) associated protein 5 MRPL22 5q33.1-q33.3 mitochondrial ribosomal protein L22 LOC285643 5q33.2 similar to Chromosome-associated kinesin KIF4A (Chromokinesin) LOC391842 5 similar to 60S ribosomal protein L6 (TAX-responsive enhancer element binding protein 107) (TAXREB107) (Neoplasm-related protein C140) LOC389340 5 LOC389340 SGCD 5q33 sarcoglycan, delta (35kDa dystrophin-associated glycoprotein) LOC153743 5q33.3 similar to protein phosphatase 1, regulatory (inhibitor) subunit 2 LOC91937 5q33.3 hypothetical protein BC008988 HAVCR1 5q33.2 hepatitis A virus cellular receptor 1 HAVCR2 5q34 hepatitis A virus cellular receptor 2 CRSP9 5q33.2 cofactor required for Sp1 transcriptional activation, subunit 9, 33kDa MGC26988 5q33.3 hypothetical protein MGC26988 ITK 5q33.1 IL2-inducible T-cell kinase CYFIP2 5q34 cytoplasmic FMR1 interacting protein 2 LOC348938 5q33.3 hypothetical protein LOC348938 ADAM19 5q32-q33 a disintegrin and metalloproteinase domain 19 (meltrin beta) SOX30 5q33 a disintegrin and metalloproteinase domain 19 (meltrin beta) LOC389341 5 similar to RIKEN cDNA 4921536K21 FLJ20546 5q33.3 hypothetical protein FLJ20546 LSM11 5q33.3 U7 snRNA-associated Sm-like protein ENTH 5q23.1-q33.3 U7 snRNA-associated Sm-like protein LOC391843 5 similar to 60S acidic ribosomal protein P2 LOC345471 5q33.3 similar to Hsp90 co-chaperone Cdc37 (Hsp90 chaperone protein kinase-targeting subunit) (p50Cdc37) LOC285721 5q33.3 hypothetical LOC285721 EBF 5q34 early B-cell factor
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 9805 - 290 - Passeos-Bueno
    - - 1576 - 256 - Passeos-Bueno
    - - 9759 32 289 - -
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrineneuroendocrinepituitary  highly
    Nervousbrain    
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Connectivebone   
    Connectivecartilage   
    Muscularsmooth   
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text heart, uterus
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • small intracellular domain
  • a single transmembrane hydrophobic domain
  • large extracellular C terminus with four cysteine residues
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Sgcd
    Homologene
    FAMILY
  • sarcoglycan beta/delta/gamma family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
    text sarcolemmal type 2 membrane protein
    basic FUNCTION
  • forming a link between the f-actin cytoskeleton and the extracellular matrix
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • associating with other sarcoglycans and sarcospan in a stoichiometrically equal complex, stabilizing the link between dystroglycan and dystrophin/utrophin
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • dystrophin binding
  • utrophin DP116, SGCE and SGCB in the Schwann cell membrane
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LGMD2F
    related resource Limb-Girdle Muscular Dystrophy, Type 2F
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS