Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Orphanet Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SGCD contributors: npt/ - updated : 13-07-2006
HGNC name sarcoglycan, delta (35kDa dystrophin-associated glycoprotein)
HGNC id 10807
Corresponding disease
LGMD2F limb girdle muscular dystrophy 2F
Location 5q33.3      Physical location : 155.753.766 - 156.194.796
Synonym name
  • 35kD dystrophin-associated glycoprotein
  • delta-sarcoglycan
  • dystrophin associated glycoprotein, delta sarcoglycan
  • placental delta sarcoglycan
  • Synonym symbol(s) DAG35, DAGD, DAPA4D, CMD1L, SGD, 35DAG, CMD1L, DAGD, MGC22567, SG-delta, SGCDP
    DNA
    TYPE functioning gene
    STRUCTURE 441.03 kb     8 Exon(s)
    10 Kb 5' upstream gene genomic sequence study
    motif Viral sequence   long terminal repeat
    text structure specific HERV-K LTR within intron 5
    MAPPING cloned Y linked N status confirmed
    RNA
    TRANSCRIPTS type messenger
    identificationnb exonstypebpproduct
    ProteinkDaAAspecific expressionYearPubmed
    - - 9805 - 290 - Passeos-Bueno
    - - 1576 - 256 - Passeos-Bueno
    - - 9759 32 289 - -
    EXPRESSION
    Type widely
    constitutive of
       expressed in (based on citations)
    organ(s)
    SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
    Cardiovascularheart   highly
    Endocrineneuroendocrinepituitary  highly
    Nervousbrain    
    Respiratorylung    
    tissue
    SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
    Connectiveadipose  highly
    Connectivebone   
    Connectivecartilage   
    Muscularsmooth   
    Muscularstriatumcardiac  
    Muscularstriatumskeletal  
    cell lineage
    cell lines
    fluid/secretion
    at STAGE
    physiological period fetal, pregnancy
    Text heart, uterus
    PROTEIN
    PHYSICAL PROPERTIES
    STRUCTURE
    motifs/domains
  • small intracellular domain
  • a single transmembrane hydrophobic domain
  • large extracellular C terminus with four cysteine residues
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to murine Sgcd
    Homologene
    FAMILY
  • sarcoglycan beta/delta/gamma family
  • CATEGORY structural protein
    SUBCELLULAR LOCALIZATION     plasma membrane
    text sarcolemmal type 2 membrane protein
    basic FUNCTION
  • forming a link between the f-actin cytoskeleton and the extracellular matrix
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • associating with other sarcoglycans and sarcospan in a stoichiometrically equal complex, stabilizing the link between dystroglycan and dystrophin/utrophin
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • dystrophin binding
  • utrophin DP116, SGCE and SGCB in the Schwann cell membrane
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) LGMD2F
    related resource Limb-Girdle Muscular Dystrophy, Type 2F
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS