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FLASH GENE

Symbol

MAP3K1

contributors: mct/npt/pgu - updated : 15-10-2018

HGNC name	mitogen-activated protein kinase kinase kinase 1
HGNC id	6848

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	Mekk1 knockout mice; Map3k1 within the syntenic region was expressed in the embryonic mouse gonad prior to, and after, sex determination
	mice lacking Map3k1 are fertile and exhibit no overt abnormalities of testis development
	Map3K1-deficient mice exhibit increased proliferation and apoptosis, and Muller glial cell overproduction in the developing retinas