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FLASH GENE

Symbol

MAP3K1

contributors: mct/npt/pgu - updated : 15-10-2018

HGNC name	mitogen-activated protein kinase kinase kinase 1
HGNC id	6848

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

XYDSDM

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function constitutional germinal mutation       mutations in MAP3K1 cause 46,XY disorders of sex development and implicate a common signal transduction pathway in human testis determination tumoral     --low   led to a potent inhibition on the invasion and migration of human pancreatic adenocarcinoma

Susceptibility

Variant & Polymorphism

Candidate gene
Marker
Therapy target
	System Type Disorder Pubmed cancer digestive pancreas may be a potential target for development of anti-invasion and metastasis drugs in pancreatic cancer

ANIMAL & CELL MODELS

	Mekk1 knockout mice; Map3k1 within the syntenic region was expressed in the embryonic mouse gonad prior to, and after, sex determination
	mice lacking Map3k1 are fertile and exhibit no overt abnormalities of testis development
	Map3K1-deficient mice exhibit increased proliferation and apoptosis, and Muller glial cell overproduction in the developing retinas