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| Foxc1 (+/-)mice have anterior segment abnormalities: small or absent Schlemm's canal, aberrantly developed trabecular meshwork, iris hypoplasia, severely eccentric pupils and displaced Schwalbe's line  | |
embryos lacking Foxc1 die pre- or perinatally including defects in the axial skeleton and cardiovascular system |
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compound Foxc1; Foxc2 homozygotes die earlier and with much more severe defects than single homozygotes alone. They have profound abnormalities in the first and second branchial arches, and the early remodeling of blood vessels |
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mice carrying the null-mutated Foxc1 gene frequently develop an anomalous double collecting system |
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hypomorphic mouse allele for Foxc1 (Foxc1(hith)) survives into adulthood which embryonic and postnatal histological analyses indicate that diminished Foxc1 protein expression in all three layers of meningeal cells leading to cortical and skull defects, detachment of radial glial endfeet, marginal zone heterotopias and cortical dyslamination |
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Foxc1-null mice have embryonic abnormalities of the rhombic lip due to loss of mesenchyme-secreted signaling molecules with subsequent loss of Atoh1 expression in vermis |
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expression of the Msx2 homeobox gene, an essential regulator of calvarial bone development is absent in the skull mesenchymal progenitors of Foxc1 mutant mice |