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FLASH GENE
Symbol B2M contributors: mct - updated : 08-09-2017
HGNC name beta-2-microglobulin
HGNC id 914
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 20 aa signal peptide of 2 kda
  • an Ig-like C1-type (immunoglobulin-like) domain
    • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus B2m (69.8 pc)
    homolog to murine B2m (68.1 pc)
    Homologene
    FAMILY
  • Ig superfamily
  • beta-2-microglobulin family
    • CATEGORY secretory , transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    text
  • secreted
    • basic FUNCTION
  • involved in antigen processing and presentation of peptide antigen via MHC class I
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
  • being a beta-chain of major histocompatibility complex class I molecules
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CD1A, CD1B, CD1C associated
  • interacting with the NTR (netrin-like) domain of PCOLCE (Morimoto 2008)
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AFHR , IMD43
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in tumoral cells with loss of HLA class 1 antigen
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS