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FLASH GENE
Symbol B2M contributors: mct - updated : 08-09-2017
HGNC name beta-2-microglobulin
HGNC id 914
EXPRESSION
Type ubiquitous
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Cardiovascularvessel   highly
Digestiveesophagus   highly
 mouth   highly
 pancreas exocrine   highly
 pharynx   predominantly
 stomach   highly
Endocrineadrenal gland   highly
Lymphoid/Immunelymph node   highly
Reproductivefemale systemuterus   
Respiratorylung   highly
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Blood / hematopoieticbone marrow  highly
Connectiveadipose  highly
Epithelialbarrier/lining   
cells
SystemCellPubmedSpeciesStageRna symbol
Skin/Tegumentkeratinocyte
cell lineage
cell lines
fluid/secretion highly in blood
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a 20 aa signal peptide of 2 kda
  • an Ig-like C1-type (immunoglobulin-like) domain
  • conjugated GlycoP
    HOMOLOGY
    interspecies homolog to rattus B2m (69.8 pc)
    homolog to murine B2m (68.1 pc)
    Homologene
    FAMILY
  • Ig superfamily
  • beta-2-microglobulin family
  • CATEGORY secretory , transport carrier
    SUBCELLULAR LOCALIZATION extracellular
        plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,endosome
    intracellular,cytoplasm,cytosolic
    text
  • secreted
  • basic FUNCTION
  • involved in antigen processing and presentation of peptide antigen via MHC class I
  • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS immunity/defense
    PATHWAY
    metabolism
    signaling
    a component
  • being a beta-chain of major histocompatibility complex class I molecules
  • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • CD1A, CD1B, CD1C associated
  • interacting with the NTR (netrin-like) domain of PCOLCE (Morimoto 2008)
  • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) AFHR , IMD43
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    tumoral   deletion    
    in tumoral cells with loss of HLA class 1 antigen
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS