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FLASH GENE
Symbol KCNA5 contributors: mct - updated : 22-10-2013
HGNC name potassium voltage-gated channel, shaker-related subfamily, member 5
HGNC id 6224
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • transmembrane (TM) protein with six putative membrane-spanning domains
  • an hydrophobic pore including the P domain with the K+ channel signature, flanked by TM domains 5 and 6, sensitive to changes in membrane potential
    • mono polymer tetramer , complex
    HOMOLOGY
    interspecies homolog to murine Kv1.5
    homolog to Drosophila shaker-related subfamily
    Homologene
    FAMILY
  • potassium channel family
  • A (Shaker) subfamily
    • CATEGORY transport channel
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm,organelle,membrane
    intracellular,cytoplasm,organelle,Golgi
    text localised on the cytoplasmic droplets and tail of ejaculated spermatozoa
    basic FUNCTION
  • mediating the voltage-dependent potassium ion permeability of excitable membranes
  • play a role in regulating the secretion of insulin in normal pancreatic islets
  • K(+)-channel involved in sperm volume regulation under physiological conditions
  • traffic and localization of KCNA3/KCNA5 heteromers implicated in the complex regulation of immune system cells
  • may play an important role in oxidative vascular endothelial injury
  • participates in the repolarization of a wide variety of cell types
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
  • tetramer forming a complex through its cytoplasmic segment T1 facing the membrane pore with four beta subunits forming the associated cytoplasmic auxiliary subunits
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
  • associating with the N terminus region of alpha subunit
  • interaction with ACTN2
  • interacting with CDH2 (modifies KCNA5 activity and is thus a novel candidate signaling molecule participating in the regulation of a variety of functions including cardiac action potential and vascular tone
  • in cardiac myocytes colocalizes with CDH2 (its expression increases following establishment of cell-cell contacts and CDH2 influences the activity of other ion channels)
  • mechanistic link among the cell adhesion molecule, CDH2, the actin-binding scaffold protein, CTTN, and KCNA5 remodeling in the heart
  • FHL1C is a binding partner for KCNA5
  • coexpression of CTNNB1 enhanced KCNA activity by fostering its membrane expression
  • associates with CDH2, caveolin and PSD95/SAP97, as well as with lipid rafts
  • CTNNB1 stimulates KCNA5 and thus participates in the shaping of the cardiac action potential and further KCNA5 sensitive cellular functions
    • cell & other
    REGULATION
    activated by DLG1 (requiring A specific N-terminal residue)
    inhibited by AMPK, that inhibits KCNA5 presumably in part by activation of NEDD4L with subsequent clearance of channel protein from the cell membrane
    Other modulation of its functional expression through Rab GTPases targeting in the cells
    ASSOCIATED DISORDERS
    corresponding disease(s) ATFB7
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in atrial fibrillation
    constitutional germinal mutation      
    in cardiac arrest patients
    Susceptibility to atrial fibrillation
    Variant & Polymorphism other increasing the atrial fibrillation
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS