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FLASH GENE

Symbol

MICB

contributors: mct - updated : 22-04-2013

HGNC name	MHC class I polypeptide-related sequence B
HGNC id	7091

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in ovarian cancer highly correlated with that of ULBP2, and high expression of ULBP2 is an indicator of poor prognosis in ovarian cancer and may relate to T cell dysfunction in the tumor microenvironment

Susceptibility

to rheumatoid arthritis (RA) to dengue shock syndrome

Variant & Polymorphism SNP	MICB*004 allele was associated with RA susceptibility
	variant increasing susceptibility for dengue shock syndrome

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS