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FLASH GENE

Symbol

MICB

contributors: mct - updated : 22-04-2013

HGNC name	MHC class I polypeptide-related sequence B
HGNC id	7091

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_005931 6 - 2497 isoform 1 42.4 383 - 1998 9480751

EXPRESSION

Type

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol blood / hematopoietic spleen         Digestive liver         Endocrine pancreas         Respiratory lung

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Connective         Epithelial secretory glandular endocrine   Epithelial secretory glandular exocrine   Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol   digestive

cell lineage

cell lines

fluid/secretion

at STAGE

physiological period

fetal

Text

spleen

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

mono polymer

dimer

HOMOLOGY

Homologene

FAMILY	MHC class I family
	MIC subfamily

CATEGORY

chaperone/stress

SUBCELLULAR LOCALIZATION

plasma membrane

basic FUNCTION	involved in the presentation of foreign antigens to the immune system
	MICA, and MICB, ligands of the KLRK1, which activates NK cells and costimulates effector T cells, are inducibly expressed under harmful conditions, such as malignancies and microbial infections

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

RNA

small molecule

protein	synergistic activity of two stress-inducible immunological danger signals, HSP70 and MICA/MICB, leads to activation and enhanced cytotoxicity of human NK cells against tumour cells
	IGF2BP3 facilitates tumor immune escape by downregulating the stress-induced ligands ULBP2 and MICB

cell & other

REGULATION

Other

activation of MICA and MICB is the result of DNA damage response activation caused by DICER1 knockdown

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in ovarian cancer highly correlated with that of ULBP2, and high expression of ULBP2 is an indicator of poor prognosis in ovarian cancer and may relate to T cell dysfunction in the tumor microenvironment

Susceptibility

to rheumatoid arthritis (RA) to dengue shock syndrome

Variant & Polymorphism SNP	MICB*004 allele was associated with RA susceptibility
	variant increasing susceptibility for dengue shock syndrome

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS