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FLASH GENE

Symbol

MICA

contributors: mct - updated : 22-04-2011

HGNC name	MHC class I polypeptide-related sequence A
HGNC id	7090

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   in ovarian cancer highly correlated with that of ULBP2, and high expression of ULBP2 is an indicator of poor prognosis in ovarian cancer and may relate to T cell dysfunction in the tumor microenvironment tumoral     --over   may be an indicator of poor prognosis in breast carcinoma ( constitutional     --over   in the gut of patients with celiac disease

Susceptibility

to IDDM, to Behcet disease to rheumatoid arthritis to viral infection, cancer and allograft rejection or graft-versus-host disease (GVHD) to Alzheimer disease (AD) to idiopathic thrombocytopenic purpura

Variant & Polymorphism other	a repeat polymorphism in TM region possibly associated with Behcet disease, not involved in ankylosing spondylitis
	MICA*A4 associated to HLA-DRB1*0405 increasing the risk of rheumatoid arthritis (RA)
	MICA*A9 having a weak protective effect on the susceptibility to RA
	polymorphisms are associated with a number of diseases related to NK activity, such as viral infection, cancer and allograft rejection or graft-versus-host disease (GVHD)
	possible association of MICA*00801 heterozygotes with AD in subjects positive for the epsilon 4 allele of apolipoprotein E
	only allele MICA*183, also known as A5.1, demonstrated an association to idiopathic thrombocytopenic purpura

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS