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FLASH GENE

Symbol

ZFP36L2

contributors: mct/npt - updated : 11-06-2020

HGNC name	zinc finger protein 36, C3H type-like 2
HGNC id	1108

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

DNA

TYPE	functioning gene
STRUCTURE	4.20 kb     2 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

provisional

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006887 2 - 3693 NP_008818 51.06 494 - 2018 29426877

EXPRESSION

Type	ubiquitous

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Cardiovascular heart       highly Digestive intestine       highly Lymphoid/Immune spleen       highly   thymus       highly Reproductive male system prostate     highly Respiratory lung       highly Skin/Tegument skin         Homo sapiens Urinary kidney       highly

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Epithelial barrier lining epidermis stratum basale   Homo sapiens Lymphoid

cells

System Cell Pubmed Species Stage Rna symbol Lymphoid/Immune macrophage

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a distinguishing putative zinc finger domain
	a repeating Cys-His motif (two C3H1-type zinc fingers)
	a tandem zinc finger (TZF) domain binding to the class II AU-rich element (ARE) in the 3' untranslated region (3' UTR) of target mRNAs and promotes their deadenylation and degradation

conjugated

MetalloP

HOMOLOGY

interspecies

homolog to murine Zfp36l2

Homologene

FAMILY	tristetraprolin family of CCCH tandem zinc finger proteins
	TIS 11 family of early response genes

CATEGORY

transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm
	intracellular,nucleus,chromatin/chromosome
text	shuttle between the nucleus and cytoplasm

basic FUNCTION	functioning in regulating the response to growth factors
	having a functional role of CCCH zinc finger genes in the regulation of macrophage activation (Liang 2008)
	role for ZFP36L1 and ZFP36L2 during thymocyte development and in the prevention of malignant transformation
	AU-rich element binding protein that is involved in RNA metabolism and definitive hematopoiesis
	ZFP36, ZFP36L1, and ZFP36L2, regulates the production of growth factors and cytokines via destabilization of the respective mRNAs
	destabilizes AU-rich element (ARE)-containing transcripts and has been implicated in female fertility
	ZFP36L1 and ZFP36L2 inhibit cell proliferation in a CCND-dependent and TP53-independent manner
	ZFP36L2 promotes the destruction of AU-rich element-containing transcripts
	is a cell cycle-regulated CCCH protein, the abundance of which is regulated post-translationally at the respective stages of the cell cycle
	is a key protein that controls S-phase progression in the case of genome instability
	ZFP36L1 and ZFP36L2 act redundantly in myogenesis
	ZFP36, ZFP36L1, and ZFP36L2, play key roles in the post-transcriptional regulation of gene expression

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA	preferentially binds to messenger RNAs that are induced or maintained at high expression levels during terminal erythroid differentiation and negatively regulates their expression levels

small molecule	metal binding,
	Zn2+

protein	interact with AU-rich elements in the 3prime untranslated region of mRNA, which leads to mRNA degradation and translational repression
	lack of the physiological down regulation of LHCGR mRNA levels by ZFP36L2 in the ovaries is associated with anovulation and oocyte meiotic arrest
	ZFP36L2, associated previously only with female fertility and hematopoiesis, regulates REST mRNA stability
	in developing B lymphocytes, the RNA-binding proteins (RBPs) ZFP36L1 and ZFP36L2 are critical for maintaining quiescence before precursor B cell receptor (pre-BCR) expression and for reestablishing quiescence after pre-BCR-induced expansion
	in addition to controlling the timing of proliferation at thymic beta-selection, posttranscriptional control by ZFP36L1/L2 limits DNA damage responses, which are known to promote thymocyte differentiation
	ZFP36L2 protein was eliminated after release from M phase, and ZYG11B-based E3 ligase plays a role in its polyubiquitination in interphase
	ZFP36L2 could be transactivated by RUNX1, which subsequently induced cell-cycle arrest and apoptosis of leukemia cells

cell & other

REGULATION

induced by	growth factors and tumor promoters tetradecanoyl phorbol acetate (TPA)
		a broad variety of growth factors and cytokines, and by scratch wounding

ASSOCIATED DISORDERS

corresponding disease(s)

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --other   dysregulation of ZFP36L2 function is associated with the pathogenesis of certain types of leukemia

Susceptibility

Variant & Polymorphism

Candidate gene	candidate TP53 target gene that may be part of the network of genes responsible for TP53-dependent apoptosis
Marker
Therapy target

ANIMAL & CELL MODELS