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FLASH GENE

Symbol

SIM1

contributors: mct - updated : 10-10-2018

HGNC name	single-minded homolog 1 (Drosophila)
HGNC id	10882

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ANIMAL & CELL MODELS

	murine S-/- die perinatally, Sim+/- development early-onset obesity, with hyperphagy but not decrease of energy expenditure
	Sim1-overexpressing transgenic mice exhibit decreased bone formation and low bone mass
	paraventricular nucleus (PVN)-Sim1 neuron ablated mice have a decreased response to fasting-induced hyperphagia