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FLASH GENE
Symbol TRIM26 contributors: mct - updated : 02-12-2013
HGNC name tripartite motif-containing 26
HGNC id 12962
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • an N-terminal RING zinc finger
  • a B box domain
  • a coiled-coil domain
  • a C-terminal B30-2/SPRY domain
    • HOMOLOGY
    interspecies homolog to rattus Trim26 (87.8 pc)
    homolog to murine Trim26 (88.9 pc)
    Homologene
    FAMILY
  • TRIM/RBCC family
  • C-IV TRIM family
  • C3HC4 subfamily
    • CATEGORY immunity/defense
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,cytoplasm,cytosolic
    text cytosolic bodies
    basic FUNCTION
  • functions in the immune response
  • TRIM26 promotes Hepatic stellate cells (HSCs) ferroptosis to suppress liver fibrosis through mediating the ubiquitination of SLC7A11
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • KDM6B-targeting of PHF20 for ubiquitination and degradation via recruitment of an E3 ligase, TRIM26
  • TRIM26 physically interacted with solute carrier family-7 member-11 (SLC7A11), a critical protein for lipid reactive oxygen species (ROS) scavenging, and mediated its ubiquitination
    • cell & other
    REGULATION
    induced by IFN-gamma and LPS
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Susceptibility
    Variant & Polymorphism
    Candidate gene
    Marker
    Therapy target
    SystemTypeDisorderPubmed
    digestiveliver 
    TRIM26-targeted SLC7A11 suppression can be a novel therapeutic strategy for liver fibrosis
    ANIMAL & CELL MODELS