| basic FUNCTION
| acting as a transcriptional regulator of insulin gene |
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inhibiting proliferation of intestinal epithelial cells |
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regulating intestine-specific genes involved in differentiation |
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involved in the regulation of specific intestinal promoters, including intestinal ALP, sucrase-isomaltase, intestinal phospholipase A/lysophospholipase (IPAL)  |
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may be an important factor in the process toward malignant transformation during the first steps of tumorigenesis |
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could play a role in the terminal differentiation of the intestine |
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inducing expression of the intestinal alkaline phosphatase gene |
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inhibiting beta-catenin/T-cell factor transcriptional activity |
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dispensable for intestinal development and that its overexpression could increase malignancy in early stages of tumourigenesis |
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enhanced the expression of PPARA gene, a master transcriptional regulator of intestinal differentiation(Park 2009) |
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with CDX2, regulate gut development and differentiation of intestinal epithelial cells |
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CDX1 and CDX2 binds to the SLC5A8 promoter, might therefore regulate the uptake of these substances in the colon |
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homeodomain transcription factor with well-established roles in anteroposterior patterning |
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pivotal role for Cdx1 function upstream of PTK7 and neural tube closure in vertebrates |
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both CDX1 and CDX2 contribute to homeostasis of the colon |
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CDX1 and CDX2 exhibit transcriptional specificity in the intestine |
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oxidative stress causes epigenetic alteration of CDX1 expression in colorectal cancer cells |
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role of CDX1 during epicardial development, suggesting that transient expression of CDX1 promotes epicardial epithelial-to-mesenchymal transition (EMT) |
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CDX1/CDX2, and KLF5 are key transcription factors involved in SHH pathway and cancer stem cells |
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CDX1 contributes to the tumorigenesis and progression of gastric cancer |
