Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol GPR6 contributors: mct - updated : 24-09-2007
HGNC name G protein-coupled receptor 6
HGNC id 4515
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments
    • conjugated GlycoP , LipoP
    HOMOLOGY
    interspecies homolog to murine Gpr6 (94.2 pc)
    intraspecies homolog to GPR3
    Homologene
    FAMILY
  • G protein coupled receptor superfamily
  • G-protein coupled receptor 1 family
    • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text located in the intracellular compartments and is capable of activating Gs-mediated signaling from these compartments (Padmanabhan 2009)
    basic FUNCTION
  • acting as a receptor for the lysosphingolipid sphingosine 1- phosphate (S1P)
  • up-regulates cAMP production in neurons, stimulates neurite outgrowth, and counteracts myelin inhibition (Tanaka 2007)
  • activating a phosphatidylinositol-calcium second messenger system
  • can signal from intracellular compartments (Padmanabhan 2009)
  • may play a role in locomotor and/or reward related behaviors (Padmanabhan 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • palmitate
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS