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FLASH GENE
Symbol GPR6 contributors: mct - updated : 24-09-2007
HGNC name G protein-coupled receptor 6
HGNC id 4515
EXPRESSION
Type
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
nervousbrainbasal nucleiputamen predominantly
Nervousbrain   specific
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period embryo
Text striatum embryonic kidney (Padmanabhan 2009)
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • seven transmembrane segments
    • conjugated GlycoP , LipoP
    HOMOLOGY
    interspecies homolog to murine Gpr6 (94.2 pc)
    intraspecies homolog to GPR3
    Homologene
    FAMILY
  • G protein coupled receptor superfamily
  • G-protein coupled receptor 1 family
    • CATEGORY receptor membrane G
    SUBCELLULAR LOCALIZATION     plasma membrane
        intracellular
    intracellular,cytoplasm
    text located in the intracellular compartments and is capable of activating Gs-mediated signaling from these compartments (Padmanabhan 2009)
    basic FUNCTION
  • acting as a receptor for the lysosphingolipid sphingosine 1- phosphate (S1P)
  • up-regulates cAMP production in neurons, stimulates neurite outgrowth, and counteracts myelin inhibition (Tanaka 2007)
  • activating a phosphatidylinositol-calcium second messenger system
  • can signal from intracellular compartments (Padmanabhan 2009)
  • may play a role in locomotor and/or reward related behaviors (Padmanabhan 2009)
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling signal transduction
    a component
  • palmitate
    • INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS