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FLASH GENE
Symbol ZNF165 contributors: mct - updated : 24-11-2020
HGNC name zinc finger protein 165
HGNC id 12953
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a SCAN box leucine-rich, mediating self association and oligomerization
  • five contiguous finger motifs, C2H2 type, Krüppel-like
    • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
    • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in transcriptional regulation
  • is a novel cancer-testis antigen capable of eliciting humoral immune response and be involved in tumour biology
  • ZNF165 is essential for recruitment of SMAD3 to shared target gene promoters and transcriptional activation
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • ZNF165 promotes TGFB1 signalling by directly suppressing the expression of negative feedback regulatory pathways
  • ZNF165 and SMAD3 cooperate to modulate TGFB1-responsive gene expression
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS