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FLASH GENE
Symbol ZNF165 contributors: mct - updated : 24-11-2020
HGNC name zinc finger protein 165
HGNC id 12953
RNA
TRANSCRIPTS type messenger
identificationnb exonstypebpproduct
ProteinkDaAAspecific expressionYearPubmed
4 - 2514 55.6 485 - 2015 26567849
2 - 1051 - 293 - 2015 26567849
4 - 2442 - 485 - 2015 26567849
4 - 2253 - 485 - 2015 26567849
4 - 1954 - 485 - 2015 26567849
EXPRESSION
Type restricted
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Reproductivemale systemtestis  specific Homo sapiensAdult
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • a SCAN box leucine-rich, mediating self association and oligomerization
  • five contiguous finger motifs, C2H2 type, Krüppel-like
    • conjugated MetalloP
    HOMOLOGY
    Homologene
    FAMILY
  • krueppel C2H2-type zinc-finger protein family
    • CATEGORY regulatory , transcription factor
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus,chromatin/chromosome
    basic FUNCTION
  • involved in transcriptional regulation
  • is a novel cancer-testis antigen capable of eliciting humoral immune response and be involved in tumour biology
  • ZNF165 is essential for recruitment of SMAD3 to shared target gene promoters and transcriptional activation
    • CELLULAR PROCESS nucleotide, transcription, regulation
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA
    small molecule metal binding,
  • Zn2+
    • protein
  • ZNF165 promotes TGFB1 signalling by directly suppressing the expression of negative feedback regulatory pathways
  • ZNF165 and SMAD3 cooperate to modulate TGFB1-responsive gene expression
    • cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS