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FLASH GENE

Symbol

ZNF165

contributors: mct - updated : 24-11-2020

HGNC name	zinc finger protein 165
HGNC id	12953

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

Location	6p22.1      Physical location : 28.048.481 - 28.057.338
Synonym name	cancer/testis antigen 53
	zinc finger and SCAN domain-containing protein 7
Synonym symbol(s)	LD65, ZSCAN7, CT53, ZPF165

DNA

TYPE	functioning gene
STRUCTURE	23.96 kb     4 Exon(s)

10 Kb 5' upstream gene genomic sequence study

MAPPING

cloned

Y

linked

N

status

confirmed

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_003447 4 - 2514 NP_003438 55.6 485 - 2015 26567849 NM_001376494 2 - 1051 NP_001363423 - 293 - 2015 26567849 NM_001376493 4 - 2442 NP_001363422 - 485 - 2015 26567849 NM_001376492 4 - 2253 NP_001363421 - 485 - 2015 26567849 NM_001376491 4 - 1954 NP_001363420 - 485 - 2015 26567849

EXPRESSION

Type	restricted

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Reproductive male system testis     specific Homo sapiens Adult

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	a SCAN box leucine-rich, mediating self association and oligomerization
	five contiguous finger motifs, C2H2 type, Krüppel-like

conjugated

MetalloP

HOMOLOGY

Homologene

FAMILY

krueppel C2H2-type zinc-finger protein family

CATEGORY

regulatory , transcription factor

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus,chromatin/chromosome

basic FUNCTION	involved in transcriptional regulation
	is a novel cancer-testis antigen capable of eliciting humoral immune response and be involved in tumour biology
	ZNF165 is essential for recruitment of SMAD3 to shared target gene promoters and transcriptional activation

CELLULAR PROCESS

nucleotide, transcription, regulation

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

small molecule	metal binding,
	Zn2+

protein	ZNF165 promotes TGFB1 signalling by directly suppressing the expression of negative feedback regulatory pathways
	ZNF165 and SMAD3 cooperate to modulate TGFB1-responsive gene expression

cell & other

REGULATION

ASSOCIATED DISORDERS

ANIMAL & CELL MODELS