Selected-GenAtlas references SOURCE GeneCards NCBI Gene Swiss-Prot Ensembl
HGNC UniGene Nucleotide OMIM UCSC
Home Page
FLASH GENE
Symbol SKIV2L contributors: mct - updated : 11-04-2012
HGNC name superkiller viralicidic activity 2-like (S. cerevisiae)
HGNC id 10898
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • DEAD/H box (Asp-Glu-Ala-Asp/His)
  • a leucine zipper domain
  • a RGD motif
  • helicase C terminal domain
    • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae -like 2
    Homologene
    FAMILY
  • helicase family
  • ski2 subfamily
    • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • RNA helicase with RNA dependent ATPase activity
  • probably involved in the regulation of translation and RNA turnover
    • CELLULAR PROCESS protein, translation regulation
    PHYSIOLOGICAL PROCESS immunity/defense
    text
  • blocking translation of poly (A) deficient mRNAs
  • antiviral activity
    • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) THES
    Susceptibility to age-related macular degeneration
    Variant & Polymorphism SNP
  • rs429608, an intronic SNP in SKIV2L is a protective factor for age-related macular degeneration
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS