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FLASH GENE
Symbol SKIV2L contributors: mct - updated : 11-04-2012
HGNC name superkiller viralicidic activity 2-like (S. cerevisiae)
HGNC id 10898
EXPRESSION
Type
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinesmall intestine   
 stomach    
Reproductivefemale systemuteruscervix  
cell lineage
cell lines
fluid/secretion
at STAGE
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
  • DEAD/H box (Asp-Glu-Ala-Asp/His)
  • a leucine zipper domain
  • a RGD motif
  • helicase C terminal domain
    • HOMOLOGY
    interspecies homolog to yeast S.cerevisiae -like 2
    Homologene
    FAMILY
  • helicase family
  • ski2 subfamily
    • CATEGORY enzyme , RNA associated
    SUBCELLULAR LOCALIZATION     intracellular
    intracellular,nucleus
    basic FUNCTION
  • RNA helicase with RNA dependent ATPase activity
  • probably involved in the regulation of translation and RNA turnover
    • CELLULAR PROCESS protein, translation regulation
    PHYSIOLOGICAL PROCESS immunity/defense
    text
  • blocking translation of poly (A) deficient mRNAs
  • antiviral activity
    • PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA binding
    RNA binding
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s) THES
    Susceptibility to age-related macular degeneration
    Variant & Polymorphism SNP
  • rs429608, an intronic SNP in SKIV2L is a protective factor for age-related macular degeneration
    • Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS