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FLASH GENE

Symbol

SKIV2L

contributors: mct - updated : 11-04-2012

HGNC name	superkiller viralicidic activity 2-like (S. cerevisiae)
HGNC id	10898

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

RNA

TRANSCRIPTS	type	messenger

identification nb exons type bp product Protein kDa AA specific expression Year Pubmed NM_006929 28 - 4187 NP_008860 - 1246 - 2000 10774746

EXPRESSION

Type

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Digestive intestine small intestine         stomach         Reproductive female system uterus cervix

cell lineage

cell lines

fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains	DEAD/H box (Asp-Glu-Ala-Asp/His)
	a leucine zipper domain
	a RGD motif
	helicase C terminal domain

HOMOLOGY

interspecies

homolog to yeast S.cerevisiae -like 2

Homologene

FAMILY	helicase family
	ski2 subfamily

CATEGORY

enzyme , RNA associated

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,nucleus

basic FUNCTION	RNA helicase with RNA dependent ATPase activity
	probably involved in the regulation of translation and RNA turnover

CELLULAR PROCESS

protein, translation regulation

PHYSIOLOGICAL PROCESS

immunity/defense

text	blocking translation of poly (A) deficient mRNAs
	antiviral activity

PATHWAY

metabolism

signaling

a component

INTERACTION

DNA

binding

RNA

binding

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

THES

Susceptibility

to age-related macular degeneration

Variant & Polymorphism SNP	rs429608, an intronic SNP in SKIV2L is a protective factor for age-related macular degeneration

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS