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FLASH GENE

Symbol

SNCB

contributors: - updated : 05-12-2006

HGNC name	synuclein, beta
HGNC id	11140

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

EXPRESSION

Type	restricted

constitutive of

expressed in	(based on citations)
organ(s)	System Organ level 1 Organ level 2 Organ level 3 Organ level 4 Level Pubmed Species Stage Rna symbol Endocrine pancreas         Nervous brain           brain midbrain substantia nigra   highly   nerve cranial nerve       Visual eye

tissue

System Tissue Tissue level 1 Tissue level 2 Level Pubmed Species Stage Rna symbol Nervous peripherous

cells

System Cell Pubmed Species Stage Rna symbol Nervous neuron

cell lineage
cell lines	highly in ovarian and breast carcinomas
fluid/secretion

at STAGE

PROTEIN

PHYSICAL PROPERTIES

STRUCTURE

motifs/domains

five imperfect repeats of 11 aminoacids with the consensus core KTKEGV

HOMOLOGY

interspecies

homolog to bovine phosphoneuroprotein (PNP14)

intraspecies

homolog to SNCA

Homologene

FAMILY

synuclein family

CATEGORY

transport carrier

SUBCELLULAR LOCALIZATION	intracellular
	intracellular,cytoplasm

basic FUNCTION	putatively involved in exocytosis of synaptic vesicles
	may play a role in neuronal plasticity

CELLULAR PROCESS

PHYSIOLOGICAL PROCESS

PATHWAY

metabolism

signaling

a component

non A/beta constituent of Alzheimer amyloid precursor

INTERACTION

DNA

RNA

small molecule

protein

cell & other

REGULATION

ASSOCIATED DISORDERS

corresponding disease(s)

FDLB

Susceptibility

Variant & Polymorphism

Candidate gene

Marker

Therapy target

ANIMAL & CELL MODELS