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FLASH GENE

Symbol

HSPA9

contributors: mct/ - updated : 21-04-2015

HGNC name	heat shock 70kDa protein 9 (mortalin)
HGNC id	5244

FLASH GENE DNA RNA EXPRESSION PROTEIN DISORDER ANIMAL & CELL MODELS

ASSOCIATED DISORDERS

corresponding disease(s)

related resource

MITOP database

Other morbid association(s)

Type Gene Modification Chromosome rearrangement Protein expression Protein Function tumoral     --over   contributes significantly to tumorigenesis in breast carcinoma tumoral     --over   correlated with malignant transformation and poor cancer prognosis ( constitutional     --low   in the mitochondrial fraction of neurons from the substantia nigra of Parkinson disease patients constitutional     --low   of HSPA8 and HSPA9 was observed in Alzheimer disease across the three brain regions compared to the controls, suggesting their participation in AD pathogenesis

Susceptibility

to Parkinson disease (PD)

Variant & Polymorphism other	putative mutations in the mortalin, although rare, could contribute to the risk of developing PD

Candidate gene
Marker
Therapy target	a good candidate target for cancer therapy
	System Type Disorder Pubmed cancer hemopathy   novel target for cancer adjuvant immunotherapy cancer digestive liver targeting HSPA9-TP53 interaction with either HSPA9 small hairpin RNA or a chemical or peptide inhibitor could induce p53-mediated tumor cell-specific apoptosis in hepatocellular carcinoma tumor     targeting HSPA9 has potential as a selective therapeutic strategy in B-Raf-mutant or MEK-ERK-driven tumors

ANIMAL & CELL MODELS