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FLASH GENE
Symbol HTR1B contributors: mct - updated : 16-01-2006
HGNC name 5-hydroxytryptamine (serotonin) receptor 1B
HGNC id 5287
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven transmembrane segments (7TM) receptor
conjugated GlycoP
HOMOLOGY
Homologene
FAMILY G protein coupled receptor superfamily
CATEGORY receptor membrane G
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • inhibiting adenylate cyclase
  • playing a crucial role in regulating serotonin neurotransmission
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with P11 (modulation of its function)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in depression-like states
    Susceptibility
  • to attention-deficit/hyperactivity disorder with preferential transmission of paternal alleles
  • to suicide
    • Variant & Polymorphism other A-161T locus, which seems to impact HTR1B transcription, could play a role in suicide predisposition by means of mediating impulsive-aggressive behaviors
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS