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FLASH GENE
Symbol HTR1B contributors: mct - updated : 16-01-2006
HGNC name 5-hydroxytryptamine (serotonin) receptor 1B
HGNC id 5287
RNA
TRANSCRIPTS type messenger
EXPRESSION
Type restricted
constitutive of
   expressed in (based on citations)
organ(s)
SystemOrgan level 1Organ level 2Organ level 3Organ level 4LevelPubmedSpeciesStageRna symbol
Digestiveintestinelarge intestinecolon  
Nervousbrain    
 brainbasal nucleistriatum  
 brainforebraincerebral cortex  
tissue
SystemTissueTissue level 1Tissue level 2LevelPubmedSpeciesStageRna symbol
Nervouscentral   
cell lineage
cell lines
fluid/secretion
at STAGE
physiological period pregnancy
Text placenta
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
seven transmembrane segments (7TM) receptor
conjugated GlycoP
HOMOLOGY
Homologene
FAMILY G protein coupled receptor superfamily
CATEGORY receptor membrane G
SUBCELLULAR LOCALIZATION     plasma membrane
basic FUNCTION
  • inhibiting adenylate cyclase
  • playing a crucial role in regulating serotonin neurotransmission
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein interacting with P11 (modulation of its function)
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    corresponding disease(s)
    Other morbid association(s)
    TypeGene ModificationChromosome rearrangementProtein expressionProtein Function
    constitutional     --low  
    in depression-like states
    Susceptibility
  • to attention-deficit/hyperactivity disorder with preferential transmission of paternal alleles
  • to suicide
    • Variant & Polymorphism other A-161T locus, which seems to impact HTR1B transcription, could play a role in suicide predisposition by means of mediating impulsive-aggressive behaviors
    Candidate gene
    Marker
    Therapy target
    ANIMAL & CELL MODELS