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FLASH GENE
Symbol NDST1 contributors: mct - updated : 16-02-2008
HGNC name N-deacetylase/N-sulfotransferase (heparan glucosaminyl) 1
HGNC id 7680
PROTEIN
PHYSICAL PROPERTIES
STRUCTURE
motifs/domains
HOMOLOGY
Homologene
FAMILY
CATEGORY enzyme
SUBCELLULAR LOCALIZATION     intracellular
intracellular,cytoplasm,cytosolic
basic FUNCTION
  • initiating and rate-limiting step in the formation of the protein-binding domain of heparan sulfate
  • bifunctional enzyme that removes N-acetyl groups from selected N-acetyl-d-glucosamine units followed by N-sulfation of the generated free amino groups
  • playing an important role forin heparan sulfate assembly in glomerular basement membrane and glomerular epithelial cells and in the pathogenesis of proteinuria in puromycin aminonucleoside nephrosis
    • CELLULAR PROCESS
    PHYSIOLOGICAL PROCESS
    PATHWAY
    metabolism
    signaling
    a component
    INTERACTION
    DNA
    RNA
    small molecule
    protein
    cell & other
    REGULATION
    ASSOCIATED DISORDERS
    ANIMAL & CELL MODELS